Antiinflammatory property of 6-chloro-5-cyclohexyl-l-indancarboxylic acid (TAI-284).
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منابع مشابه
Biological activities of metabolites of 6-chloro-5-cyclohexylindan-1-carboxylic acid (TAI-284: anti-inflammatory agent).
The pharmacological activities of five metabolites of an anti-inflammatory compound, 6-chloro-5-cyclohexylindan-1-carboxylic acid (TAI-284) were investi gated and compared with TAI-284 and phenylbutazone. The metabolite IIb (cis 3'-hydroxy-cyclohexyl, β-form) was almost equivalent to TAI-284 regarding anti inflammatory activity as estimated by the carrageenin edema test, and was mor...
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In the title compound, C13H8Cl3NO4S, the aromatic rings are oriented at a dihedral angle of 68.94 (1)° and the mol-ecule adopts a V-shape. An intra-molecular N-H⋯O inter-action generates a six-membered S(6) ring motif. In the crystal, pairs of O-H⋯O hydrogen bonds involving the carb-oxy group link the mol-ecules into inversion dimers with an R 2 (2)(8) motif. N-H⋯O and non-classical C-H⋯O inter...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1977
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.73.837